Interleukin-6(IL-6) is a multifunctional cytokine, and deregulated IL-6 gene expression has been implicated being involved in the pathogenesis of a number of diseases. So we measured the serum level of IL-6 to find a relationship between uterine
cervical cancer and serum IL-6 level.
The serum levels of IL-6 were measured in 54 patients admitted to the Severance hospital, from August, 1992 to February, 1993, of whom 27 patients were diagnosed as invasive cancer of cervix, 17 as CIN, and also utilizing 10 patients diagnosed as
uterine myoma as a control group for matched age and parity.
The average serum level of IL-6 in invasive cancer, CIN, and uterine myoma were respectively 30.33pg/ml, 37.27pg/ml, and 12.45pg/ml. In 22% of cervical cancer patients (6 of 27), and 27% of CIN patients(4 of 17 )studied blood levels of IL-6 were
detected whereas only 10% of uterine myoma (1 of 10)showed the same results. However, the difference does not seem to be statistically significant.
There was no statistically significant difference among any of the groups, and age stage did not show any significant correlation, and the results need further investigations.
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